User blog comment:AgentHoxton/Custom Death Battle: Madotsuki VS Isaac/@comment-213.120.234.109-20150429200756

One Brimstone beam would vaporize her, you know that right? Maditsuki's physical strength is probably stronger than Isaac's due to her being older and girls are more physically mature at that age(Muscle Development).

Durability: Maditsuki is paper compared to Isaac's durability, he can withstand Mega Satans giant Brimstone just in base! He can also stand two direct explosions from bombs point blank in base as well,  Maditsuki in base cannot fight against monsters or zombified school children without nearly dying.

Speed: Isaac takes this by quite a bit, he is fast enough to dodge a giant snake (Larry Jr) and dodge a giant monster trying to crush him, which he can survive that further on adds to durability, he can also dodge Mom's foot and base (as well as Satans).

Nearly all of her effects are useless in battle and shes not that smart either judging by her feats of intelligence.

Overall I don't agree with the outcome but this would be epic and amazing if this was a deathbattle!