Board Thread:General Discussion/@comment-78.16.34.119-20150226150958/@comment-4383275-20160928063728

Deadpool's vulnerability is rare and situational; Godzilla wouldn't be able to figure it out. Deathstroke might, but he wouldn't be able to access it. You know who could, however?

Batman.

In Batman: the Dark Knight Strikes Again, the Caped Crusader fought an infinitely regenerating villain with excellent fighting skills and defeating by detonating a series of explosives in the Batcave, opening up a chasm filled with lava. The villain was dropped from the Batplane into the lava and didn't regenerate from the fall because nothing was left of him to grow back.

The same could happen to Deadpool.