This category includes Death Battle, DBX and Death Race combatants who have a healing factor that allows them to heal at a superhuman rate.
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- Sailor Galaxia
- Sailor Mercury
- Sakura Haruno
- Samus Aran
- Satoru Gojo
- Sauron
- Scooby-Doo
- Scrooge McDuck
- Senketsu
- Sephiroth
- Shadow the Hedgehog
- Shang Tsung
- Shao Kahn
- Shazam
- Sigma
- Simon the Digger
- Sol Badguy
- Son Goku
- Sora
- Spawn
- Spider-Gwen
- Spider-Man
- Spider-Man 2099
- SpongeBob SquarePants
- Star Force Mega Man
- Starlight
- Static
- Steven Universe
- Stitch
- Strider Hiryu
- Sun Wukong (Journey to the West)
- Sun Wukong (RWBY)
- Superboy
- Superman
- Sōsuke Aizen
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