This category includes Death Battle combatants who are mascots of their respective companies or series.
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- Saitama
- Sam Fisher
- Samurai Jack
- Samus Aran
- Sarge
- Scooby-Doo
- Scorpion
- Scrooge McDuck
- Segata Sanshiro
- She-Ra
- Shovel Knight
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- Smokey Bear
- Sol Badguy
- Solid Snake
- Son Goku
- Sonic the Hedgehog
- Sora
- Soul Evans
- Spawn
- Spider-Man
- SpongeBob SquarePants
- Spyro the Dragon
- Star Butterfly
- Star Force Mega Man
- Steven Universe
- Stitch
- Strider Hiryu
- Sub-Zero
- Sun Wukong
- Superman
- Sweet Tooth
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